Ph.D., Mechanical Engineering, Georgia Institute of Technology, 2014
BASc, Mechanical Engineering, Bioengineering, University of Toronto, 2009
Microfluidic cell sorting based on cell mechanical properties
My research focuses on innovating novel high-throughput microfluidic devices for cell sorting based on variations in cell mechanical properties such as size, stiffness and viscoelasticity. Cell mechanical properties are indicators to the state of cells. Investigation of cell mechanical properties provides the insight into the onset and progression of human diseases. Some human diseases such as malaria, sickle cell anemia, and cancers are known to cause significant changes in cellular mechanical properties. Hence, there is a need to develop techniques and devices to continuously characterize and separate cells based on differences in mechanical properties rapidly and with high sensitivity, specificity and throughput. Microfluidic cell sorters are platforms that can utilize these newly developed biomechanical markers to expand biomedical capabilities for improvements in cell state detection and characterization.
List of publications:
@ Georgia Tech
Microfluidic cellular enrichment and separation through differences in viscoelastic deformation. Lab on a Chip, 2015, 15, 532-540. DOI: 10.1039/C4LC01150C.
Gonghao Wang, Kaci Crawford, Cory Turbyfield, Wilbur Lam, Alexander Alexeev, Todd Sulchek
Cellular enrichment through microfluidic fractionation based on cell biomechanical properties. Microfluidics and Nanofluidics, 2015. DOI: 10.1007/s10404-015-1608-y.
Gonghao Wang, Cory Turbyfield, Kaci Crawford, Alexander Alexeev, Todd Sulchek
Stiffness dependent separation of cells in a microfluidic device. PloS ONE, 2013, 8 (10). DOI: 10.1371/journal.pone.0075901.
Gonghao Wang, Wenbin Mao, Becky Byler, Krishna Patel, Caitlin Henegar, Alexander Alexeev, Todd Sulchek
Three-dimensional particle tracking in microfluidic channel flow using in and out of focus diffraction. Flow Measurement and Instrumentation, 2015, 45, 218–224. DOI:10.1016/j.flowmeasinst.
Bushra Tasadduq, Gonghao Wang, Mohamed El Banani, Wenbin Mao, Wilbur Lam, Alexander Alexeev, Todd Sulchek
Microfluidic device for separation of particles. US Patent 8356714. 2013
Gonghao Wang, Todd Sulchek, Alexander Alexeev
@ University of Toronto
A microfabricated platform for high-throughput unconfined compression of micropatterned biomaterial arrays. Biomaterials,2009 31(3) 577-584. DOI: 10.1016/j.biomaterials.2009.
Christopher Moraes, Gonghao Wang, Yu Sun, Craig A. Simmons
Honors and fellowships:
Technology Innovation: Generating Economic Results (TI:GER) Fellow, 2012.